gezeichnet
marked
Describes a person whose appearance clearly shows the traces of suffering, illness, strain, or age.
Nach den schweren Jahren sah er müde und vom Leben gezeichnet aus.
After the difficult years, he looked tired and marked by life.

marked / signed / drawn
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marked
Describes a person whose appearance clearly shows the traces of suffering, illness, strain, or age.
Nach den schweren Jahren sah er müde und vom Leben gezeichnet aus.
After the difficult years, he looked tired and marked by life.

'Gezeichnet' is the past participle of the verb 'zeichnen' (to draw/sign/mark). All meanings derive from this verb: to leave a mark on someone (zeichnen), to sign something (zeichnen), or to create a picture (zeichnen).
Das Porträt war mit Kohle gezeichnet.
The portrait was drawn with charcoal.
You can recognize the meaning from the context: if it refers to a person, it is about traces of suffering. If it refers to a document, it is about signing. If it refers to a picture, it is about art.
Sein Gesicht war von der langen Krankheit gezeichnet.
His face was marked by the long illness.
In the meaning 'marked by suffering', the word is almost always used with the preposition 'von' (by/from). The cause of the suffering then follows in the dative.
Der alte Mann war sichtlich vom Krieg gezeichnet.
The old man was visibly marked by the war.
At the end of formal letters or documents, the abbreviation 'gez.' (or 'gezeichnet' (signed)) is often used before the name of the signatory. This is a very common form.
Mit freundlichen Grüßen, gez. Dr. Meier
Kind regards, signed Dr. Meier
printed / stilted
'gedruckt' and 'gezeichnet' can both describe how an image or text ended up on paper. The difference lies in the method of production. Use 'gedruckt' when something was made with a printer or a printing process, for example a book, a poster, or a form. Use 'gezeichnet' when something was created by hand or with a drawing tool, for example with pencil, charcoal, or chalk. The words can be confused when talking about pictures on paper. If a machine or printing process is involved, 'gedruckt' fits. If someone drew the lines themselves, 'gezeichnet' fits.

An der Wand hängt eine gezeichnete Karte der Altstadt.
A drawn map of the old town hangs on the wall.
Das gedruckte Programm liegt am Eingang der Veranstaltung.
The printed program is at the entrance to the event.