der Knochen
bone
One of the hard parts that make up the skeleton of humans and vertebrates.
Er hat sich beim Fußballspielen einen Knochen gebrochen.
He broke a bone while playing soccer.

bone
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bone
One of the hard parts that make up the skeleton of humans and vertebrates.
Er hat sich beim Fußballspielen einen Knochen gebrochen.
He broke a bone while playing soccer.

A very common and fixed collocation is 'sich einen Knochen brechen' (to break a bone). This is the everyday way to talk about a bone fracture.
Sei vorsichtig auf dem Eis, damit du dir keinen Knochen brichst!
Be careful on the ice so you don't break a bone!
The idiom 'nass bis auf die Knochen sein' (to be soaked to the bone) means that someone is completely drenched, for example after heavy rain.
Wir sind ohne Schirm in einen Gewitterschauer geraten und waren nass bis auf die Knochen.
We got caught in a thunderstorm without an umbrella and were soaked to the bone.
Whether it means part of the skeleton or food for animals becomes clear from context. With injuries or in a medical context, it refers to the skeleton; with dogs or when cooking soup, it refers to an animal bone.
Das Röntgenbild zeigte, dass der Knochen nicht gebrochen ist.
The X-ray showed that the bone is not broken.
The colloquial expression 'ein harter Knochen' (a tough nut / a tough customer) can refer both to a very difficult task and to a resilient, unyielding person.
Die Verhandlung mit dem Kunden war ein harter Knochen.
The negotiation with the client was a tough nut to crack.
tooth
'der Zahn' and 'der Knochen' are both hard parts of the body. Even so, they are not used in the same way. A 'Zahn' sits in the jaw and is used for biting and chewing. A 'Knochen' belongs to the skeleton, for example in the arm, leg, or back. Learners may confuse the words because teeth are very hard and seem bone-like. In German, however, you normally do not say that a person has 'Knochen im Mund' ('bones in the mouth'). For the mouth and chewing, 'Zahn' is the correct word; for the skeleton, use 'Knochen'.

Nach dem Sturz hat die Ärztin den Knochen im Arm untersucht.
After the fall, the doctor examined the bone in his arm.
Seit gestern tut mir ein Zahn weh.
One of my teeth has been hurting since yesterday.