
die Substanz
substance
A substance or material with specific physical or chemical properties.
Im Labor wurde eine unbekannte chemische Substanz analysiert.
An unknown chemical substance was analyzed in the laboratory.
substance
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substance
A substance or material with specific physical or chemical properties.
Im Labor wurde eine unbekannte chemische Substanz analysiert.
An unknown chemical substance was analyzed in the laboratory.

substance
The essential content, core, or most important part of something, e.g. an argument, a text, or a building.
Die Substanz seiner Kritik ging in den vielen Nebensätzen verloren.
The substance of his criticism was lost in the many subordinate clauses.

assets / substance
The assets, capital, or fundamental values of a company or person. Often used in the context of preservation or loss.
Die Krise hat die finanzielle Substanz vieler kleiner Betriebe angegriffen.
The crisis has eaten into the financial substance of many small businesses.

substance
Colloquial and often euphemistic for illegal drugs.
Er wurde verhaftet, weil er verbotene Substanzen bei sich hatte.
He was arrested because he had prohibited substances on him.
The meaning of 'Substanz' (substance) depends heavily on the context. In chemistry, it means a material; in a discussion, the core of an argument; and in economics, assets.
Die Substanz des Gebäudes ist noch gut erhalten.
The substance of the building is still well preserved.
In a scientific context, 'Substanz' (substance) is often combined with adjectives such as 'chemisch' (chemical), 'giftig' (toxic), 'flüssig' (liquid), or 'fest' (solid).
Bei dem Unfall trat eine gefährliche Substanz aus.
A dangerous substance leaked out during the accident.
In a financial or personal context, there are fixed expressions. 'An die Substanz gehen' means that something is very exhausting or eats into one's reserves. 'Von der Substanz leben' means to use up savings.
Die ständigen Überstunden gehen an die Substanz.
The constant overtime is taking a toll.
In colloquial language or in official reports (e.g. by the police), 'Substanzen' (substances) is often used as a euphemistic or formal term for illegal drugs.
Der Konsum dieser Substanzen ist gesetzlich verboten.
The use of these substances is prohibited by law.
fabric / material
Stoff and Substanz can both refer to a material with particular properties. Stoff is the usual general term for this. Substanz places more emphasis on examining or identifying the material precisely based on its chemical or physical properties.

Die Fachkraft untersucht, welche Substanz die Hautreizung verursacht hat.
The specialist is examining which substance caused the skin irritation.
Dieser Stoff kann die Haut reizen, deshalb trägt Jana Handschuhe.
This substance can irritate the skin, so Jana wears gloves.