
bedeutend
significant
Very important, influential, or of great consequence.
Die Erfindung des Buchdrucks war ein bedeutendes Ereignis in der Geschichte.
The invention of printing was a significant event in history.
significant / considerable
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significant
Very important, influential, or of great consequence.
Die Erfindung des Buchdrucks war ein bedeutendes Ereignis in der Geschichte.
The invention of printing was a significant event in history.

considerable
Very large in terms of amount, extent, or degree; substantial.
Er hat einen bedeutenden Teil seines Vermögens für wohltätige Zwecke gespendet.
He donated a considerable part of his fortune to charitable causes.
'Bedeutend' (significant/considerable) is the present participle of the verb 'bedeuten' (to mean, to signify). So it describes something that has or gives meaning.
Das ist ein bedeutender Fortschritt für die Medizin.
That is a significant advance for medicine.
'Bedeutend' can stand before a noun as an adjective or be used as an adverb to intensify another adjective, often in the comparative. As an adverb, it means 'considerably' or 'significantly'.
Sie ist eine bedeutende Persönlichkeit in der Politik.
She is a significant figure in politics.
If 'bedeutend' refers to a person, an event, or an idea, it means 'important' or 'significant'. If it comes before a comparative, e.g. 'größer' (larger), or a word for quantity, e.g. 'Teil' (part), it means 'considerable' or 'considerably'.
Marie Curie war eine bedeutende Wissenschaftlerin.
Marie Curie was a significant scientist.
In the meaning 'important', 'bedeutend' is often combined with people, events, or abstract concepts: 'eine bedeutende Rolle' (a significant role), 'ein bedeutender Schritt' (a significant step), 'ein bedeutender Künstler' (a significant artist).
Die Unterzeichnung des Vertrags war ein bedeutender Schritt zum Frieden.
The signing of the treaty was a significant step toward peace.
big / great
Groß and bedeutend can both express a positive assessment of a person or achievement. Groß is more strongly an evaluative term for special quality, whereas bedeutend emphasizes influence and historical or general significance. Groß is therefore suitable for a personal judgment, while bedeutend is more appropriate when there is demonstrable impact.

Wegen ihres Einflusses gilt sie als bedeutende Künstlerin.
Because of her influence, she is considered a significant artist.
Für ihre Fans ist sie eine große Künstlerin.
To her fans, she is a great artist.