
der Beruf
profession / occupation
The trained and permanently practiced activity through which a person earns a living.
Sie ist Lehrerin von Beruf.
She is a teacher by profession.
profession / occupation
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profession / occupation
The trained and permanently practiced activity through which a person earns a living.
Sie ist Lehrerin von Beruf.
She is a teacher by profession.

vocation / calling
A task that one feels inwardly called to do; a life mission.
Für ihn war die Pflege kranker Menschen nicht nur ein Job, sondern ein wahrer Beruf.
For him, caring for sick people was not just a job, but a true calling.
The word 'Beruf' (profession/occupation) is related to the verb 'rufen' (to call). The idea behind it is that a profession is a 'Berufung' (vocation/calling) — a task one feels called to do. This also explains the second, deeper meaning of the word.
Für viele Ärzte ist ihre Arbeit mehr als nur ein Beruf, es ist eine Berufung.
For many doctors, their work is more than just a profession; it is a calling.
To ask about or state someone's profession, the expression 'von Beruf sein' (to be ... by profession) is very common. The question is: 'Was sind Sie von Beruf?' (What do you do for a living?/What are you by profession?). The answer is: 'Ich bin [Berufsbezeichnung] von Beruf.' (I am a [job title] by profession.)
Was ist Ihr Vater von Beruf?
What does your father do for a living?
When talking about careers, certain verbs are often combined with 'Beruf' (profession/occupation). Common combinations are: 'einen Beruf erlernen' (to learn a profession/trade), 'einen Beruf ergreifen' (to enter a profession), 'einen Beruf ausüben' (to practice a profession), or 'den Beruf wechseln' (to change professions).
Nach der Schule möchte sie einen kreativen Beruf erlernen.
After school, she wants to learn a creative profession.
work
Arbeit and Beruf can describe how someone earns a living. Beruf refers more to the profession someone has trained for and practices over the long term, while Arbeit means the specific job or activity. Use Beruf for a person’s established professional identity and Arbeit for their current or specific employment.

Sein Beruf ist Krankenpfleger.
He is a nurse by profession.
Seine Arbeit in der Klinik beginnt jeden Morgen um sieben Uhr.
His work at the clinic starts at seven every morning.