to lose it / spin
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to lose it
Colloquial for losing control, going crazy, panicking, or having a fit of anger.
Als er merkte, dass er seinen Pass verloren hatte, ist er komplett durchgedreht.
When he realized that he had lost his passport, he completely lost it.
'Durchdrehen' (to lose it / spin / grind) is a separable verb. The prefix 'durch' comes at the end of the main clause. In subordinate clauses and in the infinitive, the verb stays together.
Bei dieser Nachricht dreht er bestimmt durch.
He'll definitely lose it when he hears this news.
You can recognize the meaning from the subject: if a person 'durchdreht' (loses it), they lose control. If a wheel 'durchdreht' (spins), it has no traction. If you 'durchdreht' (grind) food, you chop it up.
Als sie das hörte, ist sie vor Wut fast durchgedreht.
When she heard that, she almost lost it with anger.
In the meaning 'die Kontrolle verlieren' (to lose control), the word is colloquial. The perfect tense is formed with 'sein' because it describes a change of state: 'Er ist durchgedreht' (He lost it).
Als der Computer abstürzte, bin ich fast durchgedreht.
When the computer crashed, I almost lost it.
This meaning is typical in a kitchen context. The tool, the meat grinder, is often mentioned directly in the sentence: 'etwas durch den Fleischwolf drehen' (to put something through the meat grinder).
Meine Oma hat das Fleisch für die Frikadellen immer selbst durchgedreht.
My grandma always ground the meat for the meatballs herself.
wheel / bike
'am Rad drehen' (to go crazy) and 'durchdrehen' can both mean that someone loses control or overreacts strongly. 'durchdrehen' is a single verb and often fits situations involving panic, stress, or anger. 'am Rad drehen' is a fixed colloquial expression and sounds especially vivid. Both are not very formal. 'durchdrehen' is often a bit more direct: the person is losing control right now. 'am Rad drehen' can also mean that someone is completely annoyed or overwhelmed by a situation.
Vor dem Termin dreht sie fast durch, weil der Zug wieder Verspätung hat.
Before the appointment, she almost loses it because the train is delayed again.
Bei dem langen Termin dreht das ganze Team langsam am Rad.
During the long meeting, the whole team is slowly going crazy.