
entkräften
to refute
To disprove an argument, suspicion, or accusation and take away its validity or force.
Die neuen Beweise entkräfteten die Anklage vollständig.
The new evidence completely refuted the charges.
to refute / weaken
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to refute
To disprove an argument, suspicion, or accusation and take away its validity or force.
Die neuen Beweise entkräfteten die Anklage vollständig.
The new evidence completely refuted the charges.

to weaken
To physically weaken someone or something, robbing them of their strength. This meaning is rarer and is often found in a medical or literary context.
Die lange Krankheit hatte den Patienten sichtlich entkräftet.
The long illness had visibly weakened the patient.
The word is made up of the prefix 'ent-' (to take away) and the word 'Kraft' (strength, force). 'Entkräften' therefore literally means to take strength or force away from someone or something. This applies both to the force of an argument and to a person's physical strength.
Der Anwalt konnte das Hauptargument der Gegenseite entkräften.
The lawyer was able to refute the opposing side's main argument.
'Entkräften' (to refute / weaken) is an inseparable verb because it begins with 'ent-'. The prefix remains firmly attached to the verb in all sentence forms and tenses and is never placed at the end of the sentence.
Die Zeugenaussage hat den Verdacht nicht entkräftet.
The witness statement did not refute the suspicion.
You can recognize the meaning from the object: when abstract things like an argument, an accusation, or a suspicion are the object, it means 'to refute'. When a person or living being is the object, it means 'to physically weaken'.
Die Studie entkräftet die alte Theorie. (widerlegen)
The study refutes the old theory. (to refute)
In the meaning 'to refute', the verb is frequently used with these nouns: 'einen Vorwurf entkräften' (to refute an accusation), 'ein Argument entkräften' (to refute an argument), 'einen Verdacht entkräften' (to dispel a suspicion), or 'eine Kritik entkräften' (to counter criticism).
Mit den neuen Daten konnte sie die Kritik an ihrer Arbeit entkräfen.
With the new data, she was able to refute the criticism of her work.
to deny / cover / contest
Both words can refer to an accusation or suspicion that someone rejects. „Bestreiten“ mainly says that someone considers it false, while „entkräften“ additionally shows that arguments or evidence remove its validity. Without such reasons, „bestreiten“ is usually the better choice; with them, „entkräften“ is more appropriate.

Die Firma entkräftet den Vorwurf mit ihren vollständig dokumentierten Abläufen.
The company refutes the accusation with its fully documented procedures.
Die Firma bestreitet den Vorwurf, Kundendaten falsch verwendet zu haben.
The company denies the accusation that it misused customer data.