der Space
space
A colloquial Anglicism for outer space or the universe.
Der neue Science-Fiction-Film spielt komplett im Space.
The new science fiction film is set entirely in space.

space
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space
A colloquial Anglicism for outer space or the universe.
Der neue Science-Fiction-Film spielt komplett im Space.
The new science fiction film is set entirely in space.

'Space' is a loanword from English. It is used mainly in colloquial language and in modern contexts, often connected to youth culture or professional settings.
In unserer Firma gibt es einen Kreativ-Space mit Sofas und Whiteboards.
At our company, there is a creative space with sofas and whiteboards.
You can recognize the meaning from the context. If it is about spaceships or science fiction, outer space is meant. If it is part of a word like 'Co-Working-Space' (co-working space), it refers to a physical room or area.
Die Astronauten schwebten schwerelos durch den Space.
The astronauts floated weightlessly through space.
In the meaning of 'Raum/Bereich' (room/area), 'Space' is very often used as part of compound words. Typical examples are 'Co-Working-Space' (co-working space), 'Safe Space' (safe space), or 'Maker-Space' (maker space).
Viele Universitäten bieten ihren Studierenden einen sogenannten „Safe Space“ an.
Many universities offer their students a so-called “safe space.”
place / town
'der Ort' and 'der Space' can both mean a specific room or area. 'Ort' is the normal German word and fits in almost all situations when you mean a place, a spot, or a meeting point. 'Space' is an Anglicism and sounds more modern or specialized. It is often used for rooms or areas where people work, exchange ideas, or are meant to feel safe, for example a 'Co-Working-Space' (co-working space). Learners may confuse the words because both can refer to space or location. In everyday language, 'Ort' is usually more natural; 'Space' only fits in certain modern contexts.

Im neuen Co-Working-Space können kleine Teams ruhig arbeiten.
Small teams can work quietly in the new co-working space.
Der Ort für das Treffen steht noch nicht fest.
The location for the meeting has not been decided yet.