der Keim
germ
A microorganism, especially a bacterium, virus, or fungus, that can cause disease.
Regelmäßiges Händewaschen hilft, die Verbreitung von Keimen zu reduzieren.
Regular handwashing helps reduce the spread of germs.

germ / sprout
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germ
A microorganism, especially a bacterium, virus, or fungus, that can cause disease.
Regelmäßiges Händewaschen hilft, die Verbreitung von Keimen zu reduzieren.
Regular handwashing helps reduce the spread of germs.

The noun 'der Keim' (germ/sprout) is closely related to the verb 'keimen' (to germinate/sprout). 'Keimen' means 'to begin to grow'. This image helps you understand both the botanical and the figurative meaning (the beginning of an idea).
Im Frühling beginnen die Samen im Garten zu keimen.
In spring, the seeds in the garden begin to sprout.
You can easily recognize the three main meanings from the context. In a medical context, it is about pathogens. In a botanical context, it is about the beginning of a plant. In an abstract context, it is about the origin of an idea or feeling.
Das Krankenhauspersonal muss sich vor gefährlichen Keimen schützen.
Hospital staff must protect themselves from dangerous germs.
In the medical sense, 'Keim' (germ) is often associated with negative qualities. Typical combinations are 'krankmachende Keime' (disease-causing germs), 'Keime abtöten' (to kill germs), 'Keime bekämpfen' (to fight germs), or 'multiresistente Keime' (multidrug-resistant germs).
Desinfektionsmittel soll schädliche Keime auf Oberflächen reduzieren.
Disinfectant is meant to reduce harmful germs on surfaces.
In the figurative meaning, 'Keim' (germ/seed) is often combined with feelings or ideas. Common phrases are 'der Keim des Zweifels' (the seed of doubt), 'der Keim der Hoffnung' (the seed of hope), or 'der Keim einer Idee' (the germ/seed of an idea).
Seine unbedachte Bemerkung legte den Keim für einen langen Streit.
His thoughtless remark planted the seed for a long argument.
The idiom 'etwas im Keim ersticken' (to nip something in the bud) is always used for negative developments. 'Etwas' (something) is the problem, plan, or idea that is to be stopped before it grows bigger.
Die Gerüchte über eine Krise wurden von der Firmenleitung sofort im Keim erstickt.
The rumors about a crisis were immediately nipped in the bud by the company management.
beginning
'der Anfang' and 'der Keim' can both describe the beginning of something. 'der Anfang' is neutral and simply means the first part or the start. 'der Keim' is more figurative and means the small origin from which something larger can later develop, for example an idea, a feeling, or a development. 'Anfang' fits many everyday situations. 'Keim' fits better when you want to emphasize that something is still small but can grow or develop.

In diesem kurzen Gespräch lag der Keim für eine neue Idee.
That short conversation contained the seed of a new idea.
Der Anfang des Gesprächs war ruhig, aber später wurde es sehr offen.
The beginning of the conversation was calm, but later it became very open.