die Kreuzung
intersection
A place where two or more streets or paths meet and cross.
An der nächsten Kreuzung müssen wir rechts abbiegen.
At the next intersection, we have to turn right.

intersection / crossing
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intersection
A place where two or more streets or paths meet and cross.
An der nächsten Kreuzung müssen wir rechts abbiegen.
At the next intersection, we have to turn right.

The noun 'die Kreuzung' (intersection/crossing) is derived from the verb 'kreuzen' (to cross). The ending '-ung' turns a verb into a feminine noun that often describes the process or the result of the action.
Das Kreuzen der Straße ist hier gefährlich.
Crossing the street is dangerous here.
In road traffic, you use 'an der Kreuzung' (at the intersection) for position and 'über die Kreuzung' (across/through the intersection) for movement. Pay attention to the difference between dative (where?) and accusative (to where?).
Wir treffen uns an der Kreuzung vor dem Supermarkt.
We'll meet at the intersection in front of the supermarket.
When it comes to biology, the structure 'eine Kreuzung aus ... und ...' (a crossbreed/cross of ... and ...) is often used to name the two 'parents'.
Diese Hunderasse ist eine Kreuzung aus einem Schäferhund und einem Husky.
This dog breed is a crossbreed of a German shepherd and a husky.
The context makes the meaning clear. Words like 'Straße' (street), 'Ampel' (traffic light), or 'abbiegen' (to turn) point to traffic. Terms like 'Tiere' (animals), 'Pflanzen' (plants), or 'Rasse' (breed) point to biology. Abstract things like 'Stil' (style) or 'Küche' (cuisine) point to the figurative meaning.
An der nächsten großen Kreuzung steht eine Ampel.
There is a traffic light at the next major intersection.
corner
'die Ecke' and 'die Kreuzung' can both describe places on a street where directions come together. An 'Ecke' is the area where two streets or sides meet. The word is often used when describing a nearby place, for example 'an der Ecke' (at the corner). A 'Kreuzung' is more specifically a place where two or more streets or paths cross. There, you often have to turn, wait, or pay attention to traffic. Learners may confuse the words because both occur with streets. If you only mean the street-corner area, 'Ecke' fits. If several streets really intersect, 'Kreuzung' is more precise.

Wegen des starken Verkehrs bleibt er an der Kreuzung stehen.
Because of the heavy traffic, he stops at the intersection.
Sie wartet morgen an der Ecke vor der Bäckerei.
She will wait tomorrow at the corner in front of the bakery.