
der Schluss
end
The end or final part of something.
Zum Schluss der Veranstaltung gab es ein großes Feuerwerk.
At the end of the event, there was a big fireworks display.
end / conclusion
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end
The end or final part of something.
Zum Schluss der Veranstaltung gab es ein großes Feuerwerk.
At the end of the event, there was a big fireworks display.

to stop
To end an activity, especially work for the day.
Für heute machen wir Schluss, es ist schon spät.
We'll stop here for today; it's already late.

conclusion
A logical conclusion or judgment that one draws from certain information or observations.
Aus den vorliegenden Daten lässt sich der Schluss ziehen, dass die Methode erfolgreich ist.
From the available data, the conclusion can be drawn that the method is successful.

to break up
To end a romantic relationship.
Nach langem Überlegen hat sie mit ihm Schluss gemacht.
After thinking it over for a long time, she broke up with him.

stop it!
A colloquial command to stop doing something immediately.
Ihr streitet euch schon den ganzen Tag – jetzt ist Schluss damit!
You've been arguing all day—stop it now!
'Der Schluss' (the end / conclusion) is the noun related to the verb 'schließen' (to close). The basic idea of closing or ending is found in all meanings.
Bitte schließen Sie die Tür, wenn Sie gehen.
Please close the door when you leave.
The expression 'Schluss machen' has two main meanings. 'Mit jemandem Schluss machen' means to end a relationship. 'Schluss machen' without an object or with 'für heute' means to end work or an activity.
Sie hat letzte Woche mit ihrem Freund Schluss gemacht.
She broke up with her boyfriend last week.
To describe the end of something, the expressions 'am Schluss' or 'zum Schluss' are used. Both mean 'at the end' or 'lastly'.
Am Schluss des Films haben alle geweint.
At the end of the film, everyone cried.
When 'Schluss' (conclusion) means a logical conclusion, it is almost always used in fixed expressions. The most common are 'einen Schluss ziehen' (to draw a conclusion) or 'zu einem Schluss kommen' (to come to a conclusion).
Aus diesen Fakten kann man nur einen Schluss ziehen.
From these facts, one can draw only one conclusion.
The expression 'Schluss damit!' (stop it!) is a direct command to stop an action immediately. It is often used in an annoyed or strict tone.
Hört auf zu streiten, jetzt ist Schluss damit!
Stop arguing—stop it now!
end
Ende and Schluss can both refer to the final part of a film or book. Ende tends to emphasize the neutral endpoint, while Schluss often focuses on the concluding events. If the content of the final scenes is important, Schluss is therefore usually more suitable.

Am Schluss des Films lösen die Figuren den letzten Konflikt.
In the final scenes of the film, the characters resolve the last conflict.
Das Ende des Films kam kurz vor Mitternacht.
The film ended shortly before midnight.