
abfahren
to depart
To leave a place with a vehicle (such as a train, bus, or car) in order to begin a journey.
Unser Zug fährt pünktlich um 14:05 Uhr von Gleis 7 ab.
Our train departs on time at 2:05 p.m. from platform 7.
to depart / be into
Loading your saved state.

to depart
To leave a place with a vehicle (such as a train, bus, or car) in order to begin a journey.
Unser Zug fährt pünktlich um 14:05 Uhr von Gleis 7 ab.
Our train departs on time at 2:05 p.m. from platform 7.

to be into
A colloquial expression meaning that you think someone or something is extremely great or like them very much.
Die Teenager fahren total auf die neue Rockband ab.
The teenagers are totally into the new rock band.

to drive along
To systematically drive along a certain route or through an area, often for inspection or searching.
Die Polizei muss die gesamte Route abfahren, um nach Spuren zu suchen.
The police have to drive along the entire route to look for traces.

to ski down
To go down a slope or piste on skis or a snowboard.
Bist du diese schwarze Piste schon einmal abgefahren?
Have you ever skied down this black slope?
'Abfahren' (to depart / be into) is a separable verb. The prefix 'ab-' stands at the end in a main clause. In subordinate clauses and in the infinitive with 'zu', the verb stays together.
Der Bus fährt gleich ab.
The bus is departing soon.
Since 'abfahren' describes movement away from a place, the perfect tense is always formed with the auxiliary verb 'sein' (to be).
Wir sind gestern sehr früh abgefahren.
We departed very early yesterday.
The expression 'auf etwas abfahren' (to be really into something) is purely colloquial. It is used with the preposition 'auf' and the accusative and means that you think something or someone is really great.
Mein kleiner Bruder fährt total auf Superhelden-Filme ab.
My little brother is totally into superhero movies.
In the meaning 'eine Strecke befahren' (to drive along a route), 'abfahren' is transitive and needs an accusative object. This distinguishes it from the meaning 'verlassen' (to leave), which is intransitive.
Der Busfahrer muss jeden Tag dieselbe Strecke abfahren.
The bus driver has to drive along the same route every day.
to depart / come off
Abgehen can generally express that a person or means of transport leaves a place. Abfahren more precisely refers to the start of a journey in a vehicle and is the usual choice in bus or train schedules. In that context, abgehen is less specific and depends more heavily on the context.

Der Bus fährt am frühen Morgen vom Bahnhof ab.
The bus leaves the station early in the morning.
Das Schiff geht am frühen Morgen vom Hafen ab.
The ship leaves the harbor early in the morning.